England, who have a 100% record at Twickenham under Eddie Jones, have made two changes from their opening victory against Italy and will line up against an unchanged Wales side.
Danny Care will become England's most capped scrum‑half when he wins his 78th cap and overtakes World Cup winner Matt Dawson, while Jonathan Joseph replaces Ben Te'o in the centre.
Meanwhile, Wales fly‑half Rhys Patchell has been given his chance in the absence of the injured Dan Biggar and Rhys Priestland and is one of seven players in Warren Gatland's team who have never played an international at Twickenham.
England will face Wales in the Six Nations at 4.45am tomorrow.
In other matches, Ireland will take on Italy at 2.15am tomorrow while Scotland will take on France at 3am Monday.
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